ST6GALNAC1

ST6GALNAC1
Identifiers
Aliases	ST6GALNAC1, HSY11339, SIAT7A, ST6GalNAcI, STYI, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
External IDs	OMIM: 610138; MGI: 1341826; HomoloGene: 7937; GeneCards: ST6GALNAC1; OMA:ST6GALNAC1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	76,643,786 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	116,666,333 bp
RNA expression pattern
	Top expressed in
	mucosa of sigmoid colon; ; mucosa of ileum; ; rectum; ; nasal epithelium; ; bronchial epithelial cell; ; mucosa of transverse colon; ; olfactory zone of nasal mucosa; ; jejunal mucosa; ; trachea; ; duodenum;
	Top expressed in
	conjunctival fornix; ; corneal stroma; ; lacrimal gland; ; submandibular gland; ; parotid gland; ; Paneth cell; ; muscle of thigh; ; small intestine; ; ileum; ; central gray substance of midbrain;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; sialyltransferase activity; glycosyltransferase activity; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity;
Cellular component	integral component of membrane; Golgi apparatus; membrane; Golgi membrane;
Biological process	sialylation; protein glycosylation; oligosaccharide biosynthetic process; oligosaccharide metabolic process; protein N-linked glycosylation via asparagine; ganglioside biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	55808
	20445
	ENSG00000070526
	ENSMUSG00000009588
	Q9NSC7
	Q9QZ39
	NM_001289107; NM_018414
	NM_011371
	NP_001276036; NP_060884
	NP_035501
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GALNAC1 gene. This enzyme adds a N-acetylneuraminic acid (Neu5Ac, a sialic acid) to an O-linked N-acetylgalactosamine (GalNAc) on a peptide/proteins (also called Tn antigen) with an α2-6 linkage to produce the sialyl-Tn antigen. It has been shown that the enzyme prefers threonine over serine containing GalNAc residues.