SPRED1

SPRED1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3SYX
Identifiers
Aliases	SPRED1, NFLS, PPP1R147, hSpred1, spred-1, sprouty related EVH1 domain containing 1, LGSS
External IDs	OMIM: 609291; MGI: 2150016; HomoloGene: 24919; GeneCards: SPRED1; OMA:SPRED1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	38,357,249 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	117,012,760 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; mucosa of sigmoid colon; ; Achilles tendon; ; entorhinal cortex; ; lower lobe of lung; ; germinal epithelium; ; epithelium of colon; ; pancreatic epithelial cell; ; cartilage tissue; ; Brodmann area 46;
	Top expressed in
	condyle; ; primitive streak; ; fossa; ; Region I of hippocampus proper; ; dorsomedial hypothalamic nucleus; ; substantia nigra; ; primary motor cortex; ; cingulate gyrus; ; suprachiasmatic nucleus; ; olfactory tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein serine/threonine kinase inhibitor activity; phosphatase binding; stem cell factor receptor binding; protein binding; protein kinase binding;
Cellular component	membrane; plasma membrane; caveola; cytosol; nucleus; cytoplasmic vesicle;
Biological process	negative regulation of phosphatase activity; negative regulation of peptidyl-threonine phosphorylation; regulation of protein deacetylation; MAPK cascade; multicellular organism development; fibroblast growth factor receptor signaling pathway; regulation of signal transduction; positive regulation of DNA damage response, signal transduction by p53 class mediator; vasculogenesis involved in coronary vascular morphogenesis; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of MAPK cascade; negative regulation of protein kinase activity; negative regulation of angiogenesis; regulation of MAPK cascade; negative regulation of ERK1 and ERK2 cascade;
	Sources:Amigo / QuickGO
Orthologs
	161742
	114715
	ENSG00000166068
	ENSMUSG00000027351
	Q7Z699
	Q924S8
	NM_152594
	NM_001277256; NM_033524
	NP_689807
	NP_001264185; NP_277059
	Wikidata
View/Edit Human	View/Edit Mouse

Sprouty-related, EVH1 domain-containing protein 1 (pronounced spread-1) is a protein that in humans is encoded by the SPRED1 gene located on chromosome 15q13.2 and has seven coding exons.