SPOCK1

SPOCK1
Identifiers
Aliases	SPOCK1, SPOCK, TESTICAN, TIC1, sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1, SPARC/osteonectin, cwcv and kazal like domains proteoglycan 1, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1
External IDs	OMIM: 602264; MGI: 105371; HomoloGene: 80193; GeneCards: SPOCK1; OMA:SPOCK1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	137,598,379 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	58,056,146 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; lateral nuclear group of thalamus; ; decidua; ; postcentral gyrus; ; Brodmann area 46; ; orbitofrontal cortex; ; cerebellar cortex; ; cerebellar hemisphere; ; superior frontal gyrus; ; right hemisphere of cerebellum;
	Top expressed in
	medial dorsal nucleus; ; medial geniculate nucleus; ; superior frontal gyrus; ; primary visual cortex; ; olfactory system; ; olfactory epithelium; ; cerebellar cortex; ; Gray matter of spinal cord; ; anterior horn of spinal cord; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; cysteine-type endopeptidase inhibitor activity; metalloendopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity; collagen binding; extracellular matrix binding;
Cellular component	cytoplasm; postsynaptic density; neuromuscular junction; node of Ranvier; extracellular region; sarcoplasm; extracellular space;
Biological process	negative regulation of cell-substrate adhesion; neurogenesis; negative regulation of neuron projection development; neuron migration; nervous system development; cell adhesion; regulation of cell growth; central nervous system neuron differentiation; signal transduction; negative regulation of endopeptidase activity;
	Sources:Amigo / QuickGO
Orthologs
	6695
	20745
	ENSG00000152377
	ENSMUSG00000056222
	Q08629
	Q62288
	NM_004598
	NM_001166463; NM_001166464; NM_001166465; NM_001166466; NM_009262
	NP_004589
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Testican-1 is a protein that in humans is encoded by the SPOCK1 gene.

This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is under research, though it is from the same family of glycoproteins as SPARC. It is thought its similarity to thyropin-type cysteine protease inhibitors suggests its function may be related to protease inhibition.