SNAI1

SNAI1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Y48, 3W5K, 4QLI
Identifiers
Aliases	SNAI1, SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1, snail family zinc finger 1, snail family transcriptional repressor 1
External IDs	OMIM: 604238; MGI: 98330; HomoloGene: 4363; GeneCards: SNAI1; OMA:SNAI1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	49,988,886 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	167,384,734 bp
RNA expression pattern
	Top expressed in
	gallbladder; ; left uterine tube; ; gonad; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; ascending aorta; ; upper lobe of left lung; ; right lung; ; left coronary artery; ; right auricle of heart;
	Top expressed in
	lamina propria of urethra; ; neural crest; ; tail of embryo; ; lamina propria of vagina; ; desmocranium; ; mesoderm; ; embryo; ; Primary palate; ; granulocyte; ; calvaria;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; metal ion binding; kinase binding; protein binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding;
Cellular component	nucleus; cytoplasm; nucleoplasm; pericentric heterochromatin; cytosol;
Biological process	trophoblast giant cell differentiation; roof of mouth development; regulation of bicellular tight junction assembly; positive regulation of cell migration; regulation of transcription by RNA polymerase II; epithelial to mesenchymal transition involved in endocardial cushion formation; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; multicellular organism development; negative regulation of vitamin D biosynthetic process; positive regulation of transcription, DNA-templated; negative regulation of DNA damage response, signal transduction by p53 class mediator; osteoblast differentiation; negative regulation of cell differentiation involved in embryonic placenta development; cartilage morphogenesis; hair follicle morphogenesis; left/right pattern formation; mesoderm development; negative regulation of transcription, DNA-templated; cell migration; negative regulation of transcription by RNA polymerase II; Notch signaling involved in heart development; mesoderm formation; epithelial to mesenchymal transition; positive regulation of epithelial to mesenchymal transition; heterochromatin organization; aortic valve morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	6615
	20613
	ENSG00000124216
	ENSMUSG00000042821
	O95863
	Q02085
	NM_005985
	NM_011427
	NP_005976
	NP_035557
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein SNAI1 (sometimes referred to as Snail) is a protein that in humans is encoded by the SNAI1 gene. Snail is a family of transcription factors that promote the repression of the adhesion molecule E-cadherin to regulate epithelial to mesenchymal transition (EMT) during embryonic development.