SMC4

SMC4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4U4P
Identifiers
Aliases	SMC4, CAP-C, CAPC, SMC-4, SMC4L1, hCAP-C, structural maintenance of chromosomes 4
External IDs	OMIM: 605575; MGI: 1917349; HomoloGene: 4015; GeneCards: SMC4; OMA:SMC4 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	160,434,954 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	68,941,956 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; trabecular bone; ; testicle; ; bone marrow cells; ; gonad; ; right testis; ; Achilles tendon; ; left testis; ; right coronary artery;
	Top expressed in
	human fetus; ; primary oocyte; ; tibiofemoral joint; ; fetal liver hematopoietic progenitor cell; ; spermatocyte; ; thymus; ; tail of embryo; ; maxillary prominence; ; migratory enteric neural crest cell; ; dermis;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein heterodimerization activity; nucleotide binding; protein binding; ATP binding; single-stranded DNA binding;
Cellular component	chromosome; nucleus; condensin complex; nucleoplasm; cytoplasm; cytosol; nuclear speck;
Biological process	mitotic sister chromatid segregation; meiotic chromosome segregation; cell division; cell cycle; kinetochore organization; mitotic chromosome condensation; meiotic chromosome condensation; chromosome condensation; chromosome organization;
	Sources:Amigo / QuickGO
Orthologs
	10051
	70099
	ENSG00000113810
	ENSMUSG00000034349
	Q9NTJ3
	Q8CG47
	NM_001002799; NM_001002800; NM_001288753; NM_005496
	NM_133786; NM_001356976
	NP_001002800; NP_001275682; NP_005487
	NP_598547; NP_001343905
	Wikidata
View/Edit Human	View/Edit Mouse

Structural maintenance of chromosomes protein 4 (SMC-4) also known as chromosome-associated polypeptide C (CAP-C) or XCAP-C homolog is a protein that in humans is encoded by the SMC4 gene. SMC-4 is a core subunit of condensin I and II, large protein complexes involved in high order chromosome organization, including condensation and segregation. SMC-4 protein is commonly associated with the SMC-2 protein, another protein complex within the SMC protein family. SMC-4 dimerizes with SMC-2, creating the flexible and dynamic structure of the condensin holocomplex. An over-expression of the SMC-4 protein is shown to impact carcinogenesis.