Sodium/iodide cotransporter

SLC5A5
Identifiers
Aliases	SLC5A5, NIS, TDH1, solute carrier family 5 member 5
External IDs	OMIM: 601843; MGI: 2149330; HomoloGene: 37311; GeneCards: SLC5A5; OMA:SLC5A5 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	17,895,174 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	71,345,401 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; deltoid muscle; ; mucosa of ileum; ; tibialis anterior muscle; ; body of stomach; ; testicle; ; pharynx; ; gonad; ; salivary gland; ; tonsil;
	Top expressed in
	epithelium of stomach; ; lumbar spinal ganglion; ; facial motor nucleus; ; submandibular gland; ; pyloric antrum; ; supraoptic nucleus; ; gastrula; ; Epithelium of choroid plexus; ; embryo; ; primary visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transporter activity; symporter activity; iodide transmembrane transporter activity; sodium:iodide symporter activity; transmembrane transporter activity;
Cellular component	integral component of membrane; extracellular vesicle; membrane; extracellular exosome; nucleus; plasma membrane;
Biological process	sodium ion transmembrane transport; sodium ion transport; ion transport; anion transmembrane transport; cellular response to gonadotropin stimulus; cellular response to cAMP; transmembrane transport; thyroid hormone generation; iodide transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	6528
	114479
	ENSG00000105641
	ENSMUSG00000000792
	Q92911
	Q99PN0
	NM_000453
	NM_053248
	NP_000444
	NP_444478
	Wikidata
View/Edit Human	View/Edit Mouse

The sodium/iodide cotransporter, also known as the sodium/iodide symporter (NIS), is a protein that in humans is encoded by the SLC5A5 gene. It is a transmembrane glycoprotein with a molecular weight of 87 kDa and 13 transmembrane domains, which transports two sodium cations (Na⁺) for each iodide anion (I⁻) into the cell. NIS mediated uptake of iodide into follicular cells of the thyroid gland is the first step in the synthesis of thyroid hormone.