Electrogenic sodium bicarbonate cotransporter 1

SLC4A4
Identifiers
Aliases	SLC4A4, HNBC1, KNBC, NBC1, NBC2, NBCe1-A, SLC4A5, hhNMC, pNBC, kNBC1, solute carrier family 4 member 4
External IDs	OMIM: 603345; MGI: 1927555; HomoloGene: 55776; GeneCards: SLC4A4; OMA:SLC4A4 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	71,572,087 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	89,387,512 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; external globus pallidus; ; mucosa of sigmoid colon; ; pancreatic ductal cell; ; internal globus pallidus; ; kidney tubule; ; body of pancreas; ; dorsal motor nucleus of vagus nerve; ; duodenum; ; bronchial epithelial cell;
	Top expressed in
	ciliary body; ; cerebellar vermis; ; deep cerebellar nuclei; ; human kidney; ; lobe of cerebellum; ; globus pallidus; ; dorsal tegmental nucleus; ; right kidney; ; medial vestibular nucleus; ; iris;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transporter activity; anion transmembrane transporter activity; protein binding; symporter activity; inorganic anion exchanger activity; sodium:bicarbonate symporter activity; identical protein binding;
Cellular component	integral component of membrane; plasma membrane; basolateral plasma membrane; integral component of plasma membrane; extracellular exosome; membrane;
Biological process	bicarbonate transport; anion transmembrane transport; anion transport; sodium ion transport; sodium ion transmembrane transport; ion transport; inorganic anion transport; regulation of intracellular pH; transmembrane transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	8671
	54403
	ENSG00000080493
	ENSMUSG00000060961
	Q9Y6R1
	O88343
	NM_001098484; NM_001134742; NM_003759
NM_001136260; NM_001197147; NM_018760; NM_001359211; NM_001359212;
	NM_001359213
	NP_001091954; NP_001128214; NP_003750
NP_001129732; NP_001184076; NP_061230; NP_001346140; NP_001346141;
	NP_001346142
	Wikidata
View/Edit Human	View/Edit Mouse

Electrogenic sodium bicarbonate cotransporter 1, sodium bicarbonate cotransporter is a membrane transport protein that in humans is encoded by the SLC4A4 gene.