Anion exchange protein 2

SLC4A2
Identifiers
Aliases	SLC4A2, AE2, BND3L, EPB3L1, HKB3, NBND3, solute carrier family 4 member 2
External IDs	OMIM: 109280; MGI: 109351; HomoloGene: 128699; GeneCards: SLC4A2; OMA:SLC4A2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	151,076,526 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	24,645,948 bp
RNA expression pattern
	Top expressed in
	body of stomach; ; muscle layer of sigmoid colon; ; canal of the cervix; ; right lobe of liver; ; mucosa of transverse colon; ; body of uterus; ; body of pancreas; ; stromal cell of endometrium; ; left uterine tube; ; right ovary;
	Top expressed in
	choroid plexus of fourth ventricle; ; epithelium of stomach; ; Epithelium of choroid plexus; ; vestibular membrane of cochlear duct; ; yolk sac; ; mucous cell of stomach; ; retinal pigment epithelium; ; pyloric antrum; ; molar; ; granulocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	enzyme binding; anion transmembrane transporter activity; antiporter activity; transporter activity; inorganic anion exchanger activity; sodium:bicarbonate symporter activity;
Cellular component	integral component of membrane; plasma membrane; basolateral plasma membrane; apical plasma membrane; membrane; focal adhesion; integral component of plasma membrane;
Biological process	digestive tract development; anion transport; spermatogenesis; ion transport; regulation of intracellular pH; inorganic anion transport; transmembrane transport; anion transmembrane transport; bicarbonate transport; sodium ion transmembrane transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	6522
	20535
	ENSG00000164889
	ENSMUSG00000028962
	P04920
	P13808
	NM_001199692; NM_001199693; NM_001199694; NM_003040
	NM_001253892; NM_009207
	NP_001186621; NP_001186622; NP_001186623; NP_003031
	NP_001240821; NP_033233
	Wikidata
View/Edit Human	View/Edit Mouse

Anion exchange protein 2 (AE2) is a membrane transport protein that in humans is encoded by the SLC4A2 gene. AE2 is functionally similar to the Band 3 Cl⁻/HCO3⁻ exchange protein.

Mice have been used to explore the function of AE2. AE2 contributes to basolateral membrane HCO₃⁻ transport in the gastrointestinal tract. AE2 is required for spermiogenesis in mice. AE2 is required for normal osteoclast function. The activity of AE2 is sensitive to pH.

AE3 has been suggested as a target for prevention of diabetic vasculopathy.