SLC25A22

SLC25A22
Identifiers
Aliases	SLC25A22, EIEE3, GC1, NET44, GC-1, solute carrier family 25 member 22, DEE3
External IDs	OMIM: 609302; MGI: 1915517; HomoloGene: 69383; GeneCards: SLC25A22; OMA:SLC25A22 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	798,281 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,017,805 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; anterior cingulate cortex; ; body of pancreas; ; prefrontal cortex; ; Amygdala; ; Brodmann area 9; ; anterior pituitary; ; nucleus accumbens; ; cerebellar vermis;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; intestinal villus; ; superior frontal gyrus; ; neural layer of retina; ; cerebellar cortex; ; subiculum; ; piriform cortex; ; medial dorsal nucleus; ; left lobe of liver;
	More reference expression data
	n/a
Gene ontology
Molecular function	symporter activity; L-glutamate transmembrane transporter activity; amino acid:proton symporter activity; high-affinity glutamate transmembrane transporter activity; L-aspartate transmembrane transporter activity; transmembrane transporter activity;
Cellular component	membrane; mitochondrion; mitochondrial inner membrane; integral component of membrane;
Biological process	transmembrane transport; L-glutamate transmembrane transport; ion transport; mitochondrial transport; proton transmembrane transport; aspartate transmembrane transport; malate-aspartate shuttle; L-aspartate transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	79751
	68267
	ENSG00000177542
	ENSMUSG00000019082
	Q9H936
	Q9D6M3
	NM_001191060; NM_001191061; NM_024698
	NM_001177576; NM_026646; NM_001360723; NM_001360724
	NP_001177989; NP_001177990; NP_078974
	NP_001171047; NP_080922; NP_001347652; NP_001347653
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 25 member 22 is a protein that in humans is encoded by the SLC25A22 gene. This gene encodes a mitochondrial glutamate carrier. Mutations in this gene are associated with early infantile epileptic encephalopathy. Expression of this gene is increased in colorectal tumor cells.