SKP2

SKP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FQV, 1FS1, 1FS2, 1LDK, 2ASS, 2AST
Identifiers
Aliases	SKP2, FBL1, FBXL1, FLB1, p45, S-phase kinase-associated protein 2, E3 ubiquitin protein ligase, S-phase kinase associated protein 2
External IDs	OMIM: 601436; MGI: 1351663; HomoloGene: 55942; GeneCards: SKP2; OMA:SKP2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	36,196,849 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	9,155,512 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; placenta; ; ventricular zone; ; embryo; ; gingival epithelium; ; buccal mucosa cell; ; ganglionic eminence; ; tibia; ; endothelial cell;
	Top expressed in
	maxillary prominence; ; mandibular prominence; ; primitive streak; ; abdominal wall; ; hand; ; otic vesicle; ; Rostral migratory stream; ; otic placode; ; dermis; ; human fetus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	ubiquitin protein ligase activity; protein binding; identical protein binding; ubiquitin-protein transferase activity;
Cellular component	nucleoplasm; nucleolus; SCF ubiquitin ligase complex; nucleus; cytoplasm; cytosol;
Biological process	regulation of apoptotic process; cellular response to cell-matrix adhesion; positive regulation of intracellular estrogen receptor signaling pathway; ubiquitin-dependent protein catabolic process; regulation of cell cycle; G2/M transition of mitotic cell cycle; protein ubiquitination; positive regulation of protein polyubiquitination; cell population proliferation; positive regulation of smooth muscle cell proliferation; protein polyubiquitination; protein deubiquitination; post-translational protein modification; G1/S transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; innate immune response; defense response to virus; protein K48-linked ubiquitination; immune system process; viral process;
	Sources:Amigo / QuickGO
Orthologs
	6502
	27401
	ENSG00000145604
	ENSMUSG00000054115
	Q13309
	Q9Z0Z3
	NM_001243120; NM_005983; NM_032637
	NM_001285980; NM_013787; NM_145468
	NP_001230049; NP_005974; NP_116026
	NP_001272909; NP_038815
	Wikidata
View/Edit Human	View/Edit Mouse

S-phase kinase-associated protein 2 is an enzyme that in humans is encoded by the SKP2 gene.