SGCG

SGCG
Identifiers
Aliases	SGCG, A4, DAGA4, DMDA, DMDA1, LGMD2C, MAM, SCARMD2, SCG3, TYPE, 35DAG, gamma-SG, sarcoglycan gamma, LGMDR5
External IDs	OMIM: 608896; MGI: 1346524; HomoloGene: 194; GeneCards: SGCG; OMA:SGCG - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	23,325,162 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	61,495,939 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of rectus abdominis; ; glutes; ; triceps brachii muscle; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; myocardium of left ventricle; ; thoracic diaphragm; ; vastus lateralis muscle; ; cardiac muscle tissue of right atrium; ; right ventricle;
	Top expressed in
	temporal muscle; ; soleus muscle; ; sternocleidomastoid muscle; ; interventricular septum; ; vastus lateralis muscle; ; myocardium of ventricle; ; masseter muscle; ; right ventricle; ; digastric muscle; ; plantaris muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; integral component of membrane; dystroglycan complex; cytoskeleton; membrane; sarcolemma; plasma membrane; nucleoplasm; sarcoglycan complex;
Biological process	muscle organ development; membrane organization; heart contraction; muscle cell development; cardiac muscle tissue development;
	Sources:Amigo / QuickGO
Orthologs
	6445
	24053
	ENSG00000102683
	ENSMUSG00000035296
	Q13326
	P82348
	NM_000231; NM_001378244; NM_001378245; NM_001378246
	NM_011892
	NP_000222; NP_001365173; NP_001365174; NP_001365175
	NP_036022
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-sarcoglycan is a protein that in humans is encoded by the SGCG gene. The α to δ-sarcoglycans are expressed predominantly (β) or exclusively (α, γ and δ) in striated muscle. A mutation in any of the sarcoglycan genes may lead to a secondary deficiency of the other sarcoglycan proteins, presumably due to destabilisation of the sarcoglycan complex. The disease-causing mutations in the α to δ genes cause disruptions within the dystrophin-associated protein (DAP) complex in the muscle cell membrane. The transmembrane components of the DAP complex link the cytoskeleton to the extracellular matrix in adult muscle fibres, and are essential for the preservation of the integrity of the muscle cell membrane.