SF3B3

SF3B3
Identifiers
Aliases	SF3B3, RSE1, SAP130, SF3b130, STAF130, splicing factor 3b subunit 3
External IDs	OMIM: 605592; MGI: 1289341; HomoloGene: 6579; GeneCards: SF3B3; OMA:SF3B3 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	70,577,670 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	111,573,419 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; stromal cell of endometrium; ; left ovary; ; right ovary; ; ectocervix; ; skin of leg; ; skin of abdomen; ; canal of the cervix; ; body of uterus;
	Top expressed in
	maxillary prominence; ; mandibular prominence; ; somite; ; epiblast; ; primitive streak; ; ventricular zone; ; endocardial cushion; ; tail of embryo; ; human fetus; ; dermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding; nucleic acid binding; protein-containing complex binding;
Cellular component	catalytic step 2 spliceosome; spliceosomal complex; U12-type spliceosomal complex; nucleolus; small nuclear ribonucleoprotein complex; nucleus; nucleoplasm; U2-type precatalytic spliceosome;
Biological process	RNA splicing, via transesterification reactions; mRNA splicing, via spliceosome; mRNA processing; RNA splicing; negative regulation of protein catabolic process; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	23450
	101943
	ENSG00000189091
	ENSMUSG00000033732
	Q15393
	Q921M3
	NM_012426
	NM_133953
	NP_036558
	NP_598714
	Wikidata
View/Edit Human	View/Edit Mouse

Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene.

This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.