SETDB1

SETDB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DLM, 4X3S, 5KE2
Identifiers
Aliases	SETDB1, ESET, H3-K9-HMTase4, KG1T, KMT1E, TDRD21, SET domain bifurcated 1, SET domain bifurcated histone lysine methyltransferase 1
External IDs	OMIM: 604396; MGI: 1934229; HomoloGene: 32157; GeneCards: SETDB1; OMA:SETDB1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	150,964,744 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	95,264,513 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; monocyte; ; granulocyte; ; right lobe of thyroid gland; ; right ovary; ; left ovary; ; left testis; ; right testis; ; right uterine tube; ; left lobe of thyroid gland;
	Top expressed in
	secondary oocyte; ; zygote; ; primary oocyte; ; Ileal epithelium; ; tail of embryo; ; otic placode; ; genital tubercle; ; superior surface of tongue; ; gallbladder; ; ventricular zone;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; DNA binding; promoter-specific chromatin binding; zinc ion binding; histone-lysine N-methyltransferase activity; metal ion binding; protein binding; chromatin binding; histone methyltransferase activity (H3-K9 specific);
Cellular component	intracellular membrane-bounded organelle; plasma membrane; nucleoplasm; chromosome; nucleus; cytosol; cytoplasm;
Biological process	regulation of transcription, DNA-templated; positive regulation of DNA methylation-dependent heterochromatin assembly; response to vitamin; transcription, DNA-templated; methylation; histone lysine methylation; Ras protein signal transduction; response to ethanol; chromatin organization; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; histone H3-K9 methylation;
	Sources:Amigo / QuickGO
Orthologs
	9869
	84505
	ENSG00000143379
	ENSMUSG00000015697
	Q15047
	O88974
	NM_001145415; NM_001243491; NM_012432; NM_001366417; NM_001366418
	NM_001163641; NM_001163642; NM_018877
	NP_001138887; NP_001230420; NP_036564; NP_001353346; NP_001353347
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Histone-lysine N-methyltransferase SETDB1 is an enzyme that in humans is encoded by the SETDB1 gene. SETDB1 is also known as KMT1E or H3K9 methyltransferase ESET.