SEMA6A

SEMA6A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3AFC, 3AL8, 3OKW, 3OKY
Identifiers
Aliases	SEMA6A, HT018, SEMA, SEMA6A1, SEMAQ, VIA, semaphorin 6A
External IDs	OMIM: 605885; MGI: 1203727; HomoloGene: 32426; GeneCards: SEMA6A; OMA:SEMA6A - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	116,574,823 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	47,501,937 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; external globus pallidus; ; subthalamic nucleus; ; corpus callosum; ; jejunal mucosa; ; lateral nuclear group of thalamus; ; pars reticulata; ; ventral tegmental area; ; superior vestibular nucleus; ; Pons;
	Top expressed in
	tail of embryo; ; genital tubercle; ; lumbar subsegment of spinal cord; ; yolk sac; ; Dermatocranium; ; membranous bone; ; epiblast; ; mandible; ; cartilage of the septum; ; medial geniculate nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; semaphorin receptor binding; chemorepellent activity;
Cellular component	integral component of membrane; axon; plasma membrane; membrane; integral component of plasma membrane; extracellular space;
Biological process	animal organ morphogenesis; multicellular organism development; cell surface receptor signaling pathway; cell differentiation; cytoskeleton organization; nervous system development; apoptotic process; axon guidance; positive regulation of neuron migration; negative regulation of sprouting angiogenesis; negative regulation of angiogenesis; negative regulation of cell adhesion involved in sprouting angiogenesis; cellular response to vascular endothelial growth factor stimulus; negative regulation of ERK1 and ERK2 cascade; negative regulation of vascular endothelial growth factor signaling pathway; neural crest cell migration; positive regulation of cell migration; negative regulation of axon extension involved in axon guidance; negative chemotaxis; semaphorin-plexin signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	57556
	20358
	ENSG00000092421
	ENSMUSG00000019647
	Q9H2E6
	O35464
	NM_001300780; NM_020681; NM_020796
	NM_018744; NM_001311097
	NP_001287709; NP_065847
	NP_001298026; NP_061214
	Wikidata
View/Edit Human	View/Edit Mouse

Semaphorin-6A is a protein that in humans is encoded by the SEMA6A gene.

In melanocytic cells SEMA6A gene expression may be regulated by MITF.