Robert Rayford

Robert Lee Rayford
BornFebruary 3, 1953
DiedMay 15, 1969 (aged 16)
St. Louis, Missouri, U.S.
Cause of deathPneumonia, possible AIDS-related complications
Known forAlleged first known AIDS death in the United States

Robert Lee Rayford (February 3, 1953 – May 15, 1969), sometimes identified as Robert R. due to his age, was an American teenager from Missouri who has been suggested to represent the earliest confirmed case of HIV/AIDS in North America. This is based on evidence published in 1988 in which the authors claimed that medical evidence indicated that he was "infected with a virus closely related or identical to human immunodeficiency virus type 1."

Rayford died of pneumonia, but his other symptoms baffled the doctors who treated him. A study published in 1988 reported the detection of antibodies against HIV. Results of testing for HIV genetic material were reported at a scientific conference in Australia in 1999. However, the data has never been published in a peer-reviewed medical or scientific journal.

No photos of Rayford are known to exist.