Relaxin family peptide hormones
| Relaxin 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | RLN1 | ||||||
| Alt. symbols | H1 | ||||||
| NCBI gene | 6013 | ||||||
| HGNC | 10026 | ||||||
| OMIM | 179730 | ||||||
| RefSeq | NM_006911 | ||||||
| UniProt | P04808 | ||||||
| Other data | |||||||
| Locus | Chr. 9 qter-q12 | ||||||
| |||||||
| Relaxin 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | RLN2 | ||||||
| Alt. symbols | H2, RLXH2, bA12D24.1.1, bA12D24.1.2 | ||||||
| NCBI gene | 6019 | ||||||
| HGNC | 10027 | ||||||
| OMIM | 179740 | ||||||
| PDB | 6RLX | ||||||
| RefSeq | NM_134441 | ||||||
| UniProt | P04090 | ||||||
| Other data | |||||||
| Locus | Chr. 9 qter-q12 | ||||||
| |||||||
| Relaxin 3 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | RLN3 | ||||||
| Alt. symbols | ZINS4, RXN3, H3 | ||||||
| NCBI gene | 117579 | ||||||
| HGNC | 17135 | ||||||
| OMIM | 606855 | ||||||
| RefSeq | NM_080864 | ||||||
| UniProt | Q8WXF3 | ||||||
| Other data | |||||||
| Locus | Chr. 19 p13.3 | ||||||
| |||||||
| Insulin-like peptide 3 | |
|---|---|
| Identifiers | |
| Symbol | INSL3 |
| Other data | |
| Locus | Chr. 19 |
| Insulin-like peptide 5 | |
|---|---|
| Identifiers | |
| Symbol | INSL5 |
| Other data | |
| Locus | Chr. 1 |
Relaxin family peptide hormones in humans are represented by seven members: three relaxin-like (RLN) and four insulin-like (INSL) peptides: RLN1, RLN2, RNL3, INSL3, INSL4, INSL5, INSL6. This subdivision into two classes (RLN and INSL) is based primarily on early findings, and does not reflect the evolutionary origins or physiological differences between peptides. For example, it is known that the genes coding for RLN3 and INSL5 arose from one ancestral gene, and INSL3 shares origin with RLN2 and its multiple duplicates: RLN1, INSL4, INSL6.