Regional 1 South Central
| Current season or competition: 2024–25 Regional 1 South Central | |
| Sport | Rugby union |
|---|---|
| Instituted | 2022 |
| Number of teams | 12 |
| Country | England Jersey |
| Holders | London Welsh (2024–25) |
| Most titles | Wimbledon, Havant, London Welsh (1 title) |
| Website | London & SE Division |
Regional 1 South Central is a level five league in the English rugby union system, with the twelve teams drawn from across southern and South East England. The other level five leagues are Regional 1 Midlands, Regional 1 North West, Regional 1 North East, Regional 1 South East and Regional 1 South West.
Prior to 2022, Regional 1 South Central and Regional 1 South East were part of a unified level five league known as London & South East Premier.
London Welsh are the champions and are promoted to National League 2 East