RPS6KA2

RPS6KA2
Identifiers
Aliases	RPS6KA2, HU-2, MAPKAPK1C, RSK, RSK3, S6K-alpha, S6K-alpha2, p90-RSK3, pp90RSK3, p90RSK2, ribosomal protein S6 kinase A2
External IDs	OMIM: 601685; MGI: 1342290; HomoloGene: 100680; GeneCards: RPS6KA2; OMA:RPS6KA2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	166,906,451 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	7,570,714 bp
RNA expression pattern
	Top expressed in
	inferior olivary nucleus; ; lower lobe of lung; ; internal globus pallidus; ; dorsal motor nucleus of vagus nerve; ; inferior ganglion of vagus nerve; ; C1 segment; ; optic nerve; ; right lung; ; corpus callosum; ; superior vestibular nucleus;
	Top expressed in
	granulocyte; ; muscle of thigh; ; neural layer of retina; ; tail of embryo; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; genital tubercle; ; lens; ; ventricular zone;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; metal ion binding; protein binding; protein serine/threonine/tyrosine kinase activity; ATP binding; magnesium ion binding; kinase activity; protein serine/threonine kinase activity; ribosomal protein S6 kinase activity;
Cellular component	cytoplasm; cytosol; nucleoplasm; nucleus;
Biological process	phosphorylation; negative regulation of cell cycle; protein phosphorylation; positive regulation of apoptotic process; negative regulation of cell population proliferation; signal transduction; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	6196
	20112
	ENSG00000071242
	ENSMUSG00000023809
	Q15349
	Q9WUT3
	NM_001006932; NM_021135; NM_001318936; NM_001318937; NM_001318938
	NM_011299
	NP_001006933; NP_001305865; NP_001305866; NP_001305867; NP_066958
	NP_035429
	Wikidata
View/Edit Human	View/Edit Mouse

Ribosomal protein S6 kinase alpha-2 is an enzyme that in humans is encoded by the RPS6KA2 gene.

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine and threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.