RPS6KA1

RPS6KA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WNT, 2Z7Q, 2Z7R, 2Z7S, 3RNY, 4H3P, 4NIF, 5CSJ, 5CSF, 5CSN, 5CSI
Identifiers
Aliases	RPS6KA1, HU-1, MAPKAPK1A, RSK, RSK1, p90Rsk, ribosomal protein S6 kinase A1, MAPKAPK1
External IDs	OMIM: 601684; MGI: 104558; HomoloGene: 55703; GeneCards: RPS6KA1; OMA:RPS6KA1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	26,575,030 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	133,615,108 bp
RNA expression pattern
	Top expressed in
	blood; ; granulocyte; ; mucosa of transverse colon; ; monocyte; ; duodenum; ; spleen; ; lymph node; ; appendix; ; rectum; ; bone marrow;
	Top expressed in
	granulocyte; ; crypt of lieberkuhn of small intestine; ; duodenum; ; left colon; ; jejunum; ; ileum; ; vestibular membrane of cochlear duct; ; tibiofemoral joint; ; gastric mucosa; ; epithelium of stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; metal ion binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein serine/threonine kinase activity; protein binding; protein serine/threonine/tyrosine kinase activity; ATP binding; magnesium ion binding; kinase activity; ribosomal protein S6 kinase activity;
Cellular component	nucleoplasm; nucleus; cytoplasm; cytosol;
Biological process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of translation in response to stress; intracellular signal transduction; phosphorylation; negative regulation of apoptotic process; protein phosphorylation; positive regulation of cell growth; hepatocyte proliferation; positive regulation of cell differentiation; positive regulation of hepatic stellate cell activation; cell cycle; regulation of DNA-templated transcription in response to stress; signal transduction; positive regulation of transcription by RNA polymerase II; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	6195
	20111
	ENSG00000117676; ENSG00000281877
	ENSMUSG00000003644
	Q15418
	P18653
	NM_001006665; NM_002953; NM_001330441
	NM_001285505; NM_001285506; NM_009097; NM_001378880
	NP_001006666; NP_001317370; NP_002944
	NP_001272434.1
	Wikidata
View/Edit Human	View/Edit Mouse

Ribosomal protein S6 kinase alpha-1 is an enzyme that in humans is encoded by the RPS6KA1 gene.