RIPK4

RIPK4
Identifiers
Aliases	RIPK4, ANKK2, ANKRD3, DIK, NKRD3, PKK, PPS2, RIP4, receptor interacting serine/threonine kinase 4, CHANDS
External IDs	OMIM: 605706; MGI: 1919638; HomoloGene: 10772; GeneCards: RIPK4; OMA:RIPK4 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	41,767,089 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	97,564,987 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; palpebral conjunctiva; ; oral cavity; ; amniotic fluid; ; epithelium of bronchus; ; mucosa of paranasal sinus; ; nasal epithelium; ; bronchial epithelial cell; ; mucosa of pharynx; ; kidney tubule;
	Top expressed in
	transitional epithelium of urinary bladder; ; conjunctival fornix; ; hair follicle; ; seminal vesicula; ; skin of external ear; ; skin of abdomen; ; skin of back; ; epithelium of small intestine; ; cornea; ; vestibular membrane of cochlear duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein serine/threonine kinase activity; ATP binding; kinase activity; nucleotide binding; protein kinase activity; transferase activity; protein binding;
Cellular component	membrane; cytoplasm;
Biological process	protein phosphorylation; morphogenesis of an epithelium; positive regulation of NF-kappaB transcription factor activity; phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	54101
	72388
	ENSG00000183421
	ENSMUSG00000005251
	P57078
	Q9ERK0
	NM_020639
	NM_023663
	n/a
	NP_076152
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor-interacting serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the RIPK4 gene.

The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation.