RGS20

RGS20
Identifiers
Aliases	RGS20, RGSZ1, ZGAP1, g(z)GAP, gz-GAP, regulator of G-protein signaling 20, regulator of G protein signaling 20
External IDs	OMIM: 607193; MGI: 1929866; HomoloGene: 2745; GeneCards: RGS20; OMA:RGS20 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	53,959,303 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	5,140,508 bp
RNA expression pattern
	Top expressed in
	caudate nucleus; ; nucleus accumbens; ; putamen; ; ventricular zone; ; Amygdala; ; ganglionic eminence; ; cingulate gyrus; ; anterior cingulate cortex; ; right frontal lobe; ; Brodmann area 9;
	Top expressed in
	supraoptic nucleus; ; substantia nigra; ; olfactory tubercle; ; neural layer of retina; ; ventricular zone; ; nucleus accumbens; ; globus pallidus; ; lateral septal nucleus; ; piriform cortex; ; primary motor cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; GTPase activator activity; GTPase activity;
Cellular component	trans-Golgi network; nucleus; cytoplasm; membrane; plasma membrane; cytoplasmic vesicle;
Biological process	negative regulation of signal transduction; regulation of G protein-coupled receptor signaling pathway; positive regulation of GTPase activity; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8601
	58175
	ENSG00000147509
	ENSMUSG00000002459
	O76081
	Q9QZB1
	NM_001286673; NM_001286674; NM_001286675; NM_003702; NM_170587
	NM_001177795; NM_001290372; NM_021374
	NP_001273602; NP_001273603; NP_001273604; NP_003693; NP_733466
	NP_001171266; NP_001277301; NP_067349
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of G-protein signaling 20 is a protein that in humans is encoded by the RGS20 gene.

Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM]

In melanocytic cells RGS20 gene expression may be regulated by MITF.