RC3H1

RC3H1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3X1O, 4QIK, 4QIL, 4ULW, 4YWQ
Identifiers
Aliases	RC3H1, RNF198, ROQUIN, ring finger and CCCH-type domains 1, FHL6, IMDSHY
External IDs	OMIM: 609424; MGI: 2685397; HomoloGene: 19036; GeneCards: RC3H1; OMA:RC3H1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	174,022,357 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	160,802,548 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; skin of thigh; ; mucosa of ileum; ; deltoid muscle; ; buccal mucosa cell; ; skin of hip; ; skin of arm; ; pancreatic epithelial cell; ; cardiac muscle tissue of right atrium; ; trabecular bone;
	Top expressed in
	hand; ; aortic valve; ; ascending aorta; ; otolith organ; ; utricle; ; fossa; ; condyle; ; facial motor nucleus; ; Paneth cell; ; conjunctival fornix;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin protein ligase activity; metal ion binding; mRNA binding; RNA stem-loop binding; mRNA 3'-UTR binding; RNA binding; double-stranded RNA binding; ubiquitin-protein transferase activity; protein binding; zinc ion binding; transferase activity; miRNA binding;
Cellular component	cytoplasm; P-body; cytoplasmic stress granule;
Biological process	regulation of T cell proliferation; regulation of T cell activation; B cell homeostasis; spleen development; positive regulation of NIK/NF-kappaB signaling; T cell homeostasis; T cell proliferation; regulation of gene expression; lymph node development; T follicular helper cell differentiation; negative regulation of T-helper cell differentiation; regulation of mRNA stability; positive regulation of mRNA catabolic process; regulation of germinal center formation; posttranscriptional regulation of gene expression; negative regulation of germinal center formation; negative regulation of B cell proliferation; cellular response to interleukin-1; protein ubiquitination; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; P-body assembly; regulation of T cell receptor signaling pathway; nuclear-transcribed mRNA catabolic process; negative regulation of activated T cell proliferation; 3'-UTR-mediated mRNA destabilization; protein polyubiquitination; T cell receptor signaling pathway; negative regulation of T-helper 17 cell differentiation; regulation of miRNA metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	149041
	381305
	ENSG00000135870
	ENSMUSG00000040423
	Q5TC82
	Q4VGL6
	NM_001300850; NM_001300851; NM_001300852; NM_172071
	NM_001024952
	NP_001287779; NP_001287780; NP_001287781; NP_742068; NP_001287779.1
	NP_001020123
	Wikidata
View/Edit Human	View/Edit Mouse

Ring finger and CCCH-type domains 1, also known as Roquin-1, is a protein that in humans is encoded by the RC3H1 gene.