RASGRP1

RASGRP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4L9M, 4L9U
Identifiers
Aliases	RASGRP1, CALDAG-GEFI, CALDAG-GEFII, RASGRP, hRasGRP1, RAS guanyl releasing protein 1, IMD64
External IDs	OMIM: 603962; MGI: 1314635; HomoloGene: 4195; GeneCards: RASGRP1; OMA:RASGRP1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	38,565,575 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	117,173,482 bp
RNA expression pattern
	Top expressed in
	Pons; ; cerebellar vermis; ; Brodmann area 23; ; lateral nuclear group of thalamus; ; endothelial cell; ; Brodmann area 46; ; entorhinal cortex; ; cerebellar hemisphere; ; orbitofrontal cortex; ; middle temporal gyrus;
	Top expressed in
	olfactory tubercle; ; lateral geniculate nucleus; ; medial geniculate nucleus; ; medial dorsal nucleus; ; subiculum; ; nucleus accumbens; ; pontine nuclei; ; superior frontal gyrus; ; globus pallidus; ; primary motor cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein homodimerization activity; phosphatidylcholine binding; zinc ion binding; phosphatidylserine binding; metal ion binding; diacylglycerol binding; lipid binding; guanyl-nucleotide exchange factor activity; GTPase activator activity;
Cellular component	cytoplasm; Golgi apparatus; endoplasmic reticulum membrane; membrane; mast cell granule; Golgi membrane; endoplasmic reticulum; cytosol; plasma membrane; intracellular anatomical structure;
Biological process	cell differentiation; positive regulation of protein phosphorylation; positive regulation of T cell differentiation in thymus; intracellular signal transduction; regulation of phospholipase C activity; positive regulation of MAP kinase activity; positive regulation of natural killer cell differentiation; inflammatory response to antigenic stimulus; vesicle transport along microtubule; activation of GTPase activity; regulation of GTPase activity; cytokine production; positive regulation of Ras protein signal transduction; positive regulation of natural killer cell activation; positive regulation of JNK cascade; secretory granule localization; MAPK cascade; regulation of phosphatidylinositol 3-kinase signaling; positive regulation of GTPase activity; positive regulation of granulocyte macrophage colony-stimulating factor production; protein complex oligomerization; positive regulation of ERK1 and ERK2 cascade; regulation of ERK1 and ERK2 cascade; positive regulation of tumor necrosis factor production; Ras protein signal transduction; mast cell degranulation; regulation of p38MAPK cascade; positive regulation of natural killer cell mediated cytotoxicity; signal transduction; small GTPase mediated signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	10125
	19419
	ENSG00000172575
	ENSMUSG00000027347
	O95267
	Q9Z1S3
	NM_001128602; NM_001306086; NM_005739
	NM_011246
	NP_001122074; NP_001293015; NP_005730
	NP_035376
	Wikidata
View/Edit Human	View/Edit Mouse

RAS guanyl-releasing protein 1 is a protein that in humans is encoded by the RASGRP1 gene.