RASGRF1

RASGRF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IJE
Identifiers
Aliases	RASGRF1, CDC25, CDC25L, GNRP, GRF1, GRF55, H-GRF55, PP13187, ras-GRF1, Ras protein specific guanine nucleotide releasing factor 1
External IDs	OMIM: 606600; MGI: 99694; HomoloGene: 74972; GeneCards: RASGRF1; OMA:RASGRF1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	79,090,780 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	89,909,030 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; right hemisphere of cerebellum; ; prefrontal cortex; ; right frontal lobe; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex; ; postcentral gyrus; ; islet of Langerhans; ; superior frontal gyrus;
	Top expressed in
	pontine nuclei; ; paraventricular nucleus of hypothalamus; ; dorsal tegmental nucleus; ; dorsomedial hypothalamic nucleus; ; subiculum; ; motor neuron; ; arcuate nucleus; ; suprachiasmatic nucleus; ; lateral hypothalamus; ; anterior amygdaloid area;
	More reference expression data
	n/a
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity; glutamate receptor binding;
Cellular component	cytosol; growth cone; neuron projection; plasma membrane;
Biological process	intracellular signal transduction; MAPK cascade; regulation of Rho protein signal transduction; positive regulation of GTPase activity; signal transduction; regulation of Rac protein signal transduction; regulation of synaptic plasticity; long-term memory; regulation of Ras protein signal transduction; regulation of neuronal synaptic plasticity; neuron projection development; regulation of NMDA receptor activity; activation of GTPase activity; cell population proliferation; small GTPase mediated signal transduction; positive regulation of Ras protein signal transduction; response to endoplasmic reticulum stress;
	Sources:Amigo / QuickGO
Orthologs
	5923
	19417
	ENSG00000058335
	ENSMUSG00000032356
	Q13972
	P27671
	NM_001145648; NM_002891; NM_153815
	NM_001039655; NM_011245; NM_001357743; NM_001357744
	NP_001139120; NP_002882; NP_722522
	NP_001034744; NP_035375; NP_001344672; NP_001344673
	Wikidata
View/Edit Human	View/Edit Mouse

Ras protein-specific guanine nucleotide-releasing factor 1 is a protein in humans that is encoded by the RASGRF1 gene.

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein.

The studies of the similar gene in mice suggested that the Ras-GEF activity of this protein in the brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009].