RAR-related orphan receptor alpha

RORA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1N83, 1S0X, 4S15
Identifiers
Aliases	RORA, NR1F1, ROR1, ROR2, ROR3, RZR-ALPHA, RZRA, RAR related orphan receptor A, IDDECA
External IDs	OMIM: 600825; MGI: 104661; HomoloGene: 56594; GeneCards: RORA; OMA:RORA - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	61,229,302 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	69,295,528 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; lateral nuclear group of thalamus; ; skin of hip; ; nipple; ; vulva; ; Skeletal muscle tissue of rectus abdominis; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; skin of arm; ; tibia;
	Top expressed in
	medial geniculate nucleus; ; medial dorsal nucleus; ; lateral geniculate nucleus; ; lobe of cerebellum; ; cerebellar vermis; ; skin of external ear; ; Purkinje cell; ; triceps brachii muscle; ; medial head of gastrocnemius muscle; ; deep cerebellar nuclei;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; beta-catenin binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; ligand-activated transcription factor activity; DNA-binding transcription factor activity; zinc ion binding; transcription factor binding; metal ion binding; steroid hormone receptor activity; nuclear receptor activity; core promoter sequence-specific DNA binding; protein binding; transcription coactivator binding; transcription corepressor binding; oxysterol binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	nucleoplasm; nucleus;
Biological process	negative regulation of fat cell differentiation; nitric oxide biosynthetic process; regulation of transcription, DNA-templated; cGMP metabolic process; rhythmic process; cellular response to sterol; cellular response to tumor necrosis factor; cerebellar Purkinje cell differentiation; negative regulation of I-kappaB kinase/NF-kappaB signaling; circadian regulation of gene expression; transcription, DNA-templated; cerebellar granule cell precursor proliferation; regulation of steroid metabolic process; positive regulation of transcription, DNA-templated; regulation of smoothened signaling pathway; muscle cell differentiation; intracellular receptor signaling pathway; regulation of glucose metabolic process; regulation of circadian rhythm; angiogenesis; cellular response to interleukin-1; xenobiotic metabolic process; positive regulation of circadian rhythm; positive regulation of vascular endothelial growth factor production; T-helper 17 cell differentiation; transcription initiation from RNA polymerase II promoter; negative regulation of inflammatory response; cellular response to hypoxia; triglyceride homeostasis; regulation of macrophage activation; positive regulation of transcription by RNA polymerase II; steroid hormone mediated signaling pathway; circadian rhythm; cytokine-mediated signaling pathway; cholesterol homeostasis; multicellular organism development;
	Sources:Amigo / QuickGO
Orthologs
	6095
	19883
	ENSG00000069667
	ENSMUSG00000032238
	P35398
	P51448
	NM_002943; NM_134260; NM_134261; NM_134262
	NM_013646; NM_001289916; NM_001289917
	NP_002934; NP_599022; NP_599023; NP_599024
	NP_001276845; NP_001276846; NP_038674
	Wikidata
View/Edit Human	View/Edit Mouse

RAR-related orphan receptor alpha (RORα), also known as NR1F1 (nuclear receptor subfamily 1, group F, member 1) is a nuclear receptor that in humans is encoded by the RORA gene. RORα participates in the transcriptional regulation of some genes involved in circadian rhythm. In mice, RORα is essential for development of cerebellum through direct regulation of genes expressed in Purkinje cells. It also plays an essential role in the development of type 2 innate lymphoid cells (ILC2) and mutant animals are ILC2 deficient. In addition, although present in normal numbers, the ILC3 and Th17 cells from RORα deficient mice are defective for cytokine production.