Corticosteroid 11-beta-dehydrogenase isozyme 2

HSD11B2
Identifiers
Aliases	HSD11B2, AME, AME1, HSD11K, HSD2, SDR9C3, hydroxysteroid (11-beta) dehydrogenase 2, hydroxysteroid 11-beta dehydrogenase 2
External IDs	OMIM: 614232; MGI: 104720; HomoloGene: 20088; GeneCards: HSD11B2; OMA:HSD11B2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	67,437,553 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	106,250,620 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; renal medulla; ; rectum; ; human kidney; ; mucosa of ileum; ; parotid gland; ; skin of leg; ; mucosa of sigmoid colon; ; skin of abdomen; ; minor salivary glands;
	Top expressed in
	left colon; ; right kidney; ; uterus; ; yolk sac; ; human kidney; ; otic vesicle; ; cervix; ; saccule; ; Gonadal ridge; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	NAD binding; steroid binding; oxidoreductase activity; 11-beta-hydroxysteroid dehydrogenase [NAD(P) activity];
Cellular component	cytoplasm; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; endoplasmic reticulum;
Biological process	response to hypoxia; glucocorticoid metabolic process; female pregnancy; response to steroid hormone; response to glucocorticoid; response to insulin; glucocorticoid biosynthetic process; regulation of blood volume by renal aldosterone; response to food;
	Sources:Amigo / QuickGO
Orthologs
	3291
	15484
	ENSG00000176387
	ENSMUSG00000031891
	P80365
	P51661
	NM_000196
	NM_008289
	NP_000187
	NP_032315
	Wikidata
View/Edit Human	View/Edit Mouse

Corticosteroid 11-β-dehydrogenase isozyme 2 also known as 11-β-hydroxysteroid dehydrogenase 2 is an enzyme that in humans is encoded by the HSD11B2 gene.