Cytosol nonspecific dipeptidase

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Cytosol nonspecific dipeptidase
Cytosol nonspecific dipeptidase
Identifiers
EC no.	3.4.13.18
CAS no.	9025-31-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
PMC
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PMC	articles
PubMed	articles
NCBI	proteins

CNDP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4RUH
Identifiers
Aliases	CNDP2, CN2, CPGL, HEL-S-13, HsT2298, PEPA, CNDP dipeptidase 2 (metallopeptidase M20 family), carnosine dipeptidase 2
External IDs	OMIM: 169800; MGI: 1913304; HomoloGene: 10085; GeneCards: CNDP2; OMA:CNDP2 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	74,523,454 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	84,703,827 bp
RNA expression pattern
	Top expressed in
	kidney tubule; ; renal medulla; ; endothelial cell; ; human kidney; ; mucosa of ileum; ; glomerulus; ; metanephric glomerulus; ; amniotic fluid; ; jejunal mucosa; ; corpus callosum;
	Top expressed in
	vestibular membrane of cochlear duct; ; right kidney; ; proximal tubule; ; Paneth cell; ; vestibular sensory epithelium; ; stroma of bone marrow; ; jejunum; ; human kidney; ; internal carotid artery; ; ileum;
	More reference expression data
	n/a
Gene ontology
Molecular function	carboxypeptidase activity; peptidase activity; hydrolase activity; metallopeptidase activity; dipeptidase activity; metal ion binding; alanylglutamate dipeptidase activity;
Cellular component	extracellular exosome; nucleoplasm; cytoplasm; cytosol;
Biological process	metabolism; glutathione biosynthetic process; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	55748
	66054
	ENSG00000133313
	ENSMUSG00000024644
	Q96KP4
	Q9D1A2
NM_001168499; NM_018235; NM_001370248; NM_001370249; NM_001370250;
	NM_001370254
	NM_001289531; NM_023149
NP_001161971; NP_060705; NP_001357177; NP_001357178; NP_001357179;
	NP_001357183
	NP_001276460; NP_075638
	Wikidata
View/Edit Human	View/Edit Mouse

Cytosolic non-specific dipeptidase (EC 3.4.13.18) also known as carnosine dipeptidase 2 is an enzyme that in humans is encoded by the CNDP2 gene. This enzyme catalyses the hydrolysis of dipeptides, preferentially those containing hydrophobic amino acids. The human enzyme uses manganese ions as a cofactor. In addition to its function as a peptidase, the enzyme also functions to generate N-lactoyl amino acids, such as N-lactoyl-phenylalanine, via the process of "reverse proteolysis". A similar pathway conjugates amino acids to Beta-hydroxybutyric acid.