Pralatrexate

Pralatrexate
Clinical data
Trade names	Folotyn
AHFS/Drugs.com	Monograph
License data	US FDA: Pralatrexate;
Routes of; administration	Intravenous
ATC code	L01BA05 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; US: ℞-only;
Identifiers
	IUPAC name N-(4-{1-[(2,4-diaminopteridin-6-yl)methyl]but-3-yn-1-yl}benzoyl)-L-glutamic acid;
CAS Number	146464-95-1 ;
PubChem CID	148121;
IUPHAR/BPS	6840;
DrugBank	DB06813 ;
ChemSpider	130578 ;
UNII	A8Q8I19Q20;
KEGG	D05589;
ChEBI	CHEBI:71223 ;
ChEMBL	ChEMBL1201746 ;
CompTox Dashboard (EPA)	DTXSID3048578 ;
ECHA InfoCard	100.205.791
Chemical and physical data
Formula	C23H23N7O5
Molar mass	477.481 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)[C@@H](NC(=O)c1ccc(cc1)C(CC#C)Cc2nc3c(nc2)nc(nc3N)N)CCC(=O)O;
	InChI InChI=1S/C23H23N7O5/c1-2-3-14(10-15-11-26-20-18(27-15)19(24)29-23(25)30-20)12-4-6-13(7-5-12)21(33)28-16(22(34)35)8-9-17(31)32/h1,4-7,11,14,16H,3,8-10H2,(H,28,33)(H,31,32)(H,34,35)(H4,24,25,26,29,30)/t14?,16-/m0/s1 ; Key:OGSBUKJUDHAQEA-WMCAAGNKSA-N ;
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Pralatrexate, sold under the brand name Folotyn, is a medication used for the treatment of relapsed or refractory peripheral T-cell lymphoma (PTCL).

Pralatrexate was approved for medical use in the United States in September 2009, as the first treatment for Peripheral T-cell Lymphoma (PTCL), an often aggressive type of non-Hodgkins lymphoma.