Polymorphous low-grade adenocarcinoma

Polymorphous low-grade adenocarcinoma (PLGA) is a rare, asymptomatic, slow-growing malignant salivary gland tumor. It is most commonly found in the palate.

The name of the tumor derives from the fact that:

• It has a varied microscopic architectural appearance, i.e. it is polymorphous.
• It is non-aggressive when compared to other oral cavity tumors, i.e. it is a low-grade tumor.
• It forms glands, i.e. it is an adenocarcinoma.

It affects the minor salivary glands in the area between the hard and the soft palate. Male to female ratio is 3:1, and the average age is 56 years.