Pimagedine
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| Names | |||
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| IUPAC name
2-Aminoguanidine | |||
Other names
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| Identifiers | |||
3D model (JSmol) |
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| ChEMBL | |||
| ChemSpider | |||
| ECHA InfoCard | 100.001.076 | ||
| KEGG | |||
PubChem CID |
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| UNII | |||
CompTox Dashboard (EPA) |
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| Properties | |||
| CH6N4 | |||
| Molar mass | 74.085 g/mol | ||
| Density | 1.72 g/ml | ||
| Boiling point | 261 °C (502 °F; 534 K) | ||
| log P | −1.475 | ||
| Related compounds | |||
Related compounds |
Guanidine | ||
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references | |||
Pimagedine, also known as aminoguanidine, is an investigational drug for the treatment of diabetic nephropathy that is no longer under development as a drug. Pimagedine functions as an inhibitor of diamine oxidase and nitric oxide synthase. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone, glyoxal, methylglyoxal, and related dicarbonyls. These reactive species are converted to less reactive heterocycles by this condensation reaction.