Peucemycin

Peucemycin
Identifiers
3D model (JSmol)
  • InChI=1S/C24H30O6/c1-4-7-9-19-21(26)13-18-14-22(27)29-15-17(12-16(6-3)8-5-2)10-11-20(25)23(28)24(19)30-18/h7-13,20,23,25,28H,4-6,14-15H2,1-3H3/b9-7+,11-10+,16-8+,17-12-
    Key: MCGPXTDENHMOKQ-WQQCRNHGSA-N
  • CC\C=C\C1=C2OC(CC(=O)OC/C(=C\C(\CC)=C\CC)/C=C/C(O)C2O)=CC1=O
Properties
C24H30O6
Molar mass 414.498 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Peucemycin is a polyketide produced by Streptomyces peucetius, a Gram-positive filamentous bacteria that also produces the anticancer compounds daunorubicin and doxorubicin. This compound was elucidated from a cryptic biosynthetic gene cluster and is produced under temperature-specific conditions for bacterial growth (metabolite is present at 18 °C but not 28 °C). Peucemycin has demonstrated bioactivity against growth of S. aureus, P. hauseri, and S. enterica and also is weakly active against cancer cell lines. Peucemycin is biosynthesized through a Type 1 PKS system.

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