Paralytic (gene)

Paralytic
Identifiers
Symbolpara
Alt. symbolsbss, sbl, olfD, DmNav, DmNav1, DmNav
NCBI gene32619
UniProtP35500
Other data
LocusChr. X 16,455,230 - 16,533,368
Search for
StructuresSwiss-model
DomainsInterPro

Paralytic is a gene in the fruit fly, Drosophila melanogaster, which encodes a voltage gated sodium channel within D. melanogaster neurons. This gene is essential for locomotive activity in the fly. There are 9 different para alleles, composed of a minimum of 26 exons within over 78kb of genomic DNA. The para gene undergoes alternative splicing to produce subtypes of the channel protein. Flies with mutant forms of paralytic are used in fly models of seizures, since seizures can be easily induced in these flies.