PURA

PURA
Identifiers
Aliases	PURA, PUR-ALPHA, PUR1, PURALPHA, MRD31, purine-rich element binding protein A, purine rich element binding protein A, NEDRIHF
External IDs	OMIM: 600473; MGI: 103079; HomoloGene: 4279; GeneCards: PURA; OMA:PURA - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	140,125,619 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	36,425,588 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; Epithelium of choroid plexus; ; dorsal motor nucleus of vagus nerve; ; postcentral gyrus; ; ventral tegmental area; ; superior vestibular nucleus; ; subthalamic nucleus; ; inferior ganglion of vagus nerve; ; Pons;
	Top expressed in
	ventral tegmental area; ; cerebellar vermis; ; superior colliculus; ; lobe of cerebellum; ; mammillary body; ; dorsomedial hypothalamic nucleus; ; pontine nuclei; ; dorsal tegmental nucleus; ; lateral geniculate nucleus; ; median eminence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; double-stranded telomeric DNA binding; DNA-binding transcription factor activity; transcription factor binding; purine-rich negative regulatory element binding; translation repressor activity, mRNA regulatory element binding; single-stranded DNA binding; protein binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; double-stranded DNA binding; SMAD binding; RNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding;
Cellular component	cytoplasm; soma; dendrite; DNA replication factor A complex; nucleus; dendrite cytoplasm; postsynapse; glutamatergic synapse;
Biological process	cell differentiation; negative regulation of translation; regulation of transcription, DNA-templated; transcription, DNA-templated; nervous system development; regulation of cell population proliferation; DNA replication initiation; positive regulation of cell population proliferation; negative regulation of transcription, DNA-templated; DNA unwinding involved in DNA replication; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; dendritic transport of messenger ribonucleoprotein complex; lymphocyte proliferation; epithelial cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	5813
	19290
	ENSG00000185129
	ENSMUSG00000043991
	Q00577
	P42669
	NM_005859
	NM_008989
	NP_005850
	NP_033015
	Wikidata
View/Edit Human	View/Edit Mouse

Pur-alpha is a protein that in humans is encoded by the PURA gene located at chromosome 5, band q31.

Pur-alpha is an ancient, multi-functional DNA- and RNA-binding protein. PURA is expressed in every human tissue, where it exists as a protein of 322 amino acids. According to convention, PURA, the gene, is written italicized in all upper case letters. Pur-alpha, the protein, is written with the first letter capitalized and can be found listed as Pur-alpha, Pur-α, Pura, Puralpha, Pur alpha and Pur1.