PTTG1IP

PTTG1IP
Identifiers
Aliases	PTTG1IP, C21orf1, C21orf3, PBF, pituitary tumor-transforming 1 interacting protein, PTTG1 interacting protein, PTTG1IP1
External IDs	OMIM: 603784; MGI: 2652132; HomoloGene: 3203; GeneCards: PTTG1IP; OMA:PTTG1IP - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	44,873,903 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	77,434,566 bp
RNA expression pattern
	Top expressed in
	visceral pleura; ; tibia; ; parietal pleura; ; cartilage tissue; ; palpebral conjunctiva; ; placenta; ; decidua; ; parotid gland; ; right coronary artery; ; bronchial epithelial cell;
	Top expressed in
	epithelium of stomach; ; ascending aorta; ; aortic valve; ; transitional epithelium of urinary bladder; ; mucous cell of stomach; ; decidua; ; utricle; ; tunica media of zone of aorta; ; endothelial cell of lymphatic vessel; ; ciliary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	p53 binding; protein binding; molecular function;
Cellular component	cytoplasm; integral component of membrane; extracellular exosome; membrane; nucleus; nucleoplasm;
Biological process	negative regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of protein ubiquitination; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; protein import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	754
	108705
	ENSG00000183255
	ENSMUSG00000009291
	P53801
	Q8R143
	NM_001286822; NM_004339
	NM_145925
	NP_001273751; NP_004330
	NP_666037
	Wikidata
View/Edit Human	View/Edit Mouse

Pituitary tumor-transforming gene 1 protein-interacting protein (PTTG1), also known as PTTG1-binding factor (PBF), is a poorly characterised protein that in humans is encoded by the PTTG1IP gene located within the chromosomal region 21q22.3.