PTPRS

PTPRS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FH7, 2YD2, 2YD3, 2YD9, 4BPC, 4PBX
Identifiers
Aliases	PTPRS, PTPSIGMA, protein tyrosine phosphatase, receptor type S, R-PTP-S, R-PTP-sigma, protein tyrosine phosphatase receptor type S
External IDs	OMIM: 601576; MGI: 97815; HomoloGene: 20626; GeneCards: PTPRS; OMA:PTPRS - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	5,340,812 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	56,783,483 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; sural nerve; ; ventricular zone; ; gastric mucosa; ; stromal cell of endometrium; ; left uterine tube; ; right hemisphere of cerebellum; ; right ovary; ; right lung; ; right coronary artery;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; ganglionic eminence; ; ventricular zone; ; renal corpuscle; ; superior frontal gyrus; ; Rostral migratory stream; ; primary visual cortex; ; genital tubercle; ; subiculum; ; CA3 field;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatase activity; protein binding; hydrolase activity; phosphoprotein phosphatase activity; protein tyrosine phosphatase activity; heparin binding; chondroitin sulfate binding; heparan sulfate proteoglycan binding;
Cellular component	integral component of membrane; integral component of plasma membrane; extracellular exosome; membrane; plasma membrane; integral component of synaptic vesicle membrane; integral component of postsynaptic density membrane; postsynaptic density; cell junction; axon; synaptic vesicle membrane; cytoplasmic vesicle; cell projection; neuron projection; perikaryon; synapse; postsynaptic membrane; Schaffer collateral - CA1 synapse; glutamatergic synapse; integral component of presynaptic membrane;
Biological process	cell adhesion; dephosphorylation; protein dephosphorylation; negative regulation of interferon-alpha production; negative regulation of interferon-beta production; negative regulation of toll-like receptor 9 signaling pathway; negative regulation of neuron projection development; spinal cord development; cerebellum development; hippocampus development; cerebral cortex development; corpus callosum development; negative regulation of axon extension; peptidyl-tyrosine dephosphorylation; negative regulation of collateral sprouting; negative regulation of axon regeneration; negative regulation of dendritic spine development; establishment of endothelial intestinal barrier; modulation of chemical synaptic transmission; synapse organization; regulation of postsynaptic density assembly; synaptic membrane adhesion;
	Sources:Amigo / QuickGO
Orthologs
	5802
	19280
	ENSG00000105426
	ENSMUSG00000013236
	Q13332
	B0V2N1
NM_002850; NM_130853; NM_130854; NM_130855; NM_001394011;
	NM_001394012; NM_001394013
	NM_001252453; NM_001252455; NM_001252456; NM_011218
	NP_002841; NP_570923; NP_570924; NP_570925
	NP_001239382; NP_001239384; NP_001239385; NP_035348
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor-type tyrosine-protein phosphatase S, also known as R-PTP-S, R-PTP-sigma, or PTPσ, is an enzyme that in humans is encoded by the PTPRS gene.