PTPRN

PTPRN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2I1Y, 2QT7, 3N01, 3N4W, 3NG8, 3NP5
Identifiers
Aliases	PTPRN, IA-2, IA-2/PTP, IA2, ICA512, R-PTP-N, protein tyrosine phosphatase, receptor type N, protein tyrosine phosphatase receptor type N
External IDs	OMIM: 601773; MGI: 102765; HomoloGene: 48142; GeneCards: PTPRN; OMA:PTPRN - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	219,309,648 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	75,241,146 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; Brodmann area 10; ; right frontal lobe; ; right hemisphere of cerebellum; ; pituitary gland; ; anterior cingulate cortex; ; anterior pituitary; ; frontal pole; ; nucleus accumbens; ; Brodmann area 9;
	Top expressed in
	superior frontal gyrus; ; primary visual cortex; ; entorhinal cortex; ; perirhinal cortex; ; dentate gyrus of hippocampal formation granule cell; ; CA3 field; ; dorsomedial hypothalamic nucleus; ; nucleus of stria terminalis; ; central gray substance of midbrain; ; supraoptic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	spectrin binding; protein binding; protein tyrosine phosphatase activity; transcription factor binding; ubiquitin-like protein ligase binding; GTPase binding; phosphatase activity; hydrolase activity;
Cellular component	axon terminus; integral component of membrane; perikaryon; endosome; Golgi apparatus; cell projection; membrane; synaptic vesicle; plasma membrane; transport vesicle membrane; synapse; secretory granule; axon; cell junction; soma; cytoplasmic vesicle; nucleus;
Biological process	luteinization; cytokine-mediated signaling pathway; response to reactive oxygen species; insulin secretion; response to glucose; response to estrogen; response to insulin; response to cAMP; dense core granule maturation; insulin secretion involved in cellular response to glucose stimulus; transcription, DNA-templated; regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; positive regulation of type B pancreatic cell proliferation; peptidyl-tyrosine dephosphorylation; protein dephosphorylation; dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	5798
	19275
	ENSG00000054356
	ENSMUSG00000026204
	Q16849
	Q60673
	NM_001199763; NM_001199764; NM_002846
	NM_008985; NM_001359281
	NP_001186692; NP_001186693; NP_002837
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor-type tyrosine-protein phosphatase-like N, also called "IA-2", is an enzyme that in humans is encoded by the PTPRN gene.