PTP4A3

PTP4A3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1R6H, 1V3A, 2MBC
Identifiers
Aliases	PTP4A3, PRL-3, PRL-R, PRL3, protein tyrosine phosphatase type IVA, member 3, protein tyrosine phosphatase 4A3
External IDs	OMIM: 606449; MGI: 1277098; HomoloGene: 22500; GeneCards: PTP4A3; OMA:PTP4A3 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	141,432,454 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	73,630,615 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; gastric mucosa; ; muscle of thigh; ; left ventricle; ; gastrocnemius muscle; ; right auricle of heart; ; skeletal muscle tissue; ; anterior pituitary; ; tibial arteries; ; right coronary artery;
	Top expressed in
	muscle of thigh; ; extensor digitorum longus muscle; ; blood; ; plantaris muscle; ; medial head of gastrocnemius muscle; ; tibialis anterior muscle; ; neural layer of retina; ; digastric muscle; ; knee joint; ; triceps brachii muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein tyrosine phosphatase activity; prenylated protein tyrosine phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; hydrolase activity; protein tyrosine/serine/threonine phosphatase activity; protein binding;
Cellular component	endosome; plasma membrane; early endosome; membrane; nucleus; cytoplasm;
Biological process	Notch signaling pathway; protein dephosphorylation; positive regulation of vascular permeability; regulation of vascular endothelial growth factor signaling pathway; endothelial cell migration; dephosphorylation; peptidyl-tyrosine dephosphorylation; regulation of transcription, DNA-templated; positive regulation of NIK/NF-kappaB signaling; positive regulation of establishment of protein localization; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologs
	11156
	19245
	ENSG00000184489; ENSG00000275575
	ENSMUSG00000059895
	O75365
	Q9D658
	NM_007079; NM_032611
	NM_001166388; NM_001166389; NM_001166390; NM_008975; NM_001357591
	NP_009010; NP_116000
	NP_001159860; NP_001159861; NP_001159862; NP_033001; NP_001344520
	Wikidata
View/Edit Human	View/Edit Mouse

Protein tyrosine phosphatase type IVA 3 is an enzyme that in humans is encoded by the PTP4A3 gene.

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist.