PSMC2

PSMC2
Identifiers
Aliases	PSMC2, MSS1, Nbla10058, S7, proteasome 26S subunit, ATPase 2, RPT1
External IDs	OMIM: 154365; MGI: 109555; HomoloGene: 2096; GeneCards: PSMC2; OMA:PSMC2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	103,370,346 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	22,008,785 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of biceps brachii; ; epithelium of nasopharynx; ; sperm; ; gingival epithelium; ; visceral pleura; ; palpebral conjunctiva; ; skin of hip; ; Skeletal muscle tissue of rectus abdominis; ; parietal pleura; ; tibia;
	Top expressed in
	facial motor nucleus; ; primitive streak; ; motor neuron; ; superior cervical ganglion; ; medullary collecting duct; ; seminiferous tubule; ; Epithelium of choroid plexus; ; ureter; ; fossa; ; hair follicle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ATPase activity; protein binding; TBP-class protein binding; ATP binding; hydrolase activity; proteasome-activating activity;
Cellular component	nuclear proteasome complex; proteasome regulatory particle, base subcomplex; membrane; proteasome accessory complex; nucleoplasm; cytosolic proteasome complex; proteasome complex; nucleus; extracellular region; cytoplasm; cytosol; secretory granule lumen; ficolin-1-rich granule lumen; P-body; cytoplasmic ribonucleoprotein granule; dendritic spine;
Biological process	positive regulation of RNA polymerase II transcription preinitiation complex assembly; regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; ubiquitin-dependent protein catabolic process; regulation of mRNA stability; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; MAPK cascade; Fc-epsilon receptor signaling pathway; protein catabolic process; NIK/NF-kappaB signaling; osteoblast differentiation; ubiquitin-dependent ERAD pathway; anaphase-promoting complex-dependent catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; Wnt signaling pathway, planar cell polarity pathway; viral process; positive regulation of proteasomal protein catabolic process; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; neutrophil degranulation; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5701
	19181
	ENSG00000161057
	ENSMUSG00000028932
	P35998
	P46471; Q8BVQ9
	NM_001204453; NM_002803
	NM_011188; NM_001368661
	NP_001191382; NP_002794
	NP_035318; NP_001355590
	Wikidata
View/Edit Human	View/Edit Mouse

26S protease regulatory subunit 7, also known as 26S proteasome AAA-ATPase subunit Rpt1, is an enzyme that in humans is encoded by the PSMC2 gene This protein is one of the 19 essential subunits of a complete assembled 19S proteasome complex. Six 26S proteasome AAA-ATPase subunits (Rpt1 (this protein), Rpt2, Rpt3, Rpt4, Rpt5, and Rpt6) together with four non-ATPase subunits (Rpn1, Rpn2, Rpn10, and Rpn13) form the base sub complex of 19S regulatory particle for proteasome complex.