PSMA2

PSMA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4R3O, 4R67, 5A0Q
Identifiers
Aliases	PSMA2, HC3, MU, PMSA2, PSC2, proteasome subunit alpha 2, proteasome 20S subunit alpha 2
External IDs	OMIM: 176842; MGI: 104885; HomoloGene: 2081; GeneCards: PSMA2; OMA:PSMA2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	42,932,185 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	14,848,821 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; gastrocnemius muscle; ; islet of Langerhans; ; mucosa of transverse colon; ; right adrenal gland; ; endometrium; ; right adrenal cortex; ; body of pancreas; ; right lobe of liver;
	Top expressed in
	somite; ; primitive streak; ; mandibular prominence; ; endocardial cushion; ; medial ganglionic eminence; ; maxillary prominence; ; hand; ; endothelial cell of lymphatic vessel; ; facial motor nucleus; ; abdominal wall;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	endopeptidase activity; peptidase activity; protein binding; threonine-type endopeptidase activity; hydrolase activity;
Cellular component	cytoplasm; cytosol; nucleoplasm; proteasome complex; extracellular exosome; nucleus; proteasome core complex; extracellular region; secretory granule lumen; ficolin-1-rich granule lumen; proteasome core complex, alpha-subunit complex; P-body;
Biological process	regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of mRNA stability; ubiquitin-dependent protein catabolic process; positive regulation of canonical Wnt signaling pathway; response to virus; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; proteolysis; MAPK cascade; Fc-epsilon receptor signaling pathway; NIK/NF-kappaB signaling; anaphase-promoting complex-dependent catabolic process; proteolysis involved in cellular protein catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; Wnt signaling pathway, planar cell polarity pathway; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; neutrophil degranulation; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5683
	19166
	ENSG00000106588
	ENSMUSG00000015671
	P25787
	P49722
	NM_002787
	NM_008944
	NP_002778
	NP_032970
	Wikidata
View/Edit Human	View/Edit Mouse

Proteasome subunit alpha type-2 is a protein that in humans is encoded by the PSMA2 gene. This protein is one of the 17 essential subunits (alpha subunits 1–7, constitutive beta subunits 1–7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex.