Trypsin 1

PRSS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FXY, 1TRN, 2RA3, 4WWY, 4WXV
Identifiers
Aliases	PRSS1, TRP1, TRY1, TRY4, TRYP1, Trypsin 1, protease, serine 1, serine protease 1
External IDs	OMIM: 276000; MGI: 3687012; HomoloGene: 134623; GeneCards: PRSS1; OMA:PRSS1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	142,753,076 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	41,334,848 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; islet of Langerhans; ; duodenum; ; body of stomach; ; fundus; ; ectocervix; ; right coronary artery; ; testicle; ; left uterine tube; ; right lobe of liver;
	Top expressed in
	pancreas; ; islet of Langerhans; ; stomach; ; granulocyte; ; colon; ; duodenum; ; esophagus; ; jejunum; ; quadriceps femoris muscle; ; liver;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; serine-type endopeptidase activity; hydrolase activity; metal ion binding; serine-type peptidase activity;
Cellular component	extracellular region; blood microparticle; extracellular exosome; extracellular space; collagen-containing extracellular matrix;
Biological process	digestion; cobalamin metabolic process; extracellular matrix disassembly; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	5644
	436522
	ENSG00000274247; ENSG00000204983
	ENSMUSG00000071521
	P07477
	Q792Z1
	NM_002769
	NM_001038996
	NP_002760
	NP_001034085
	Wikidata
View/Edit Human	View/Edit Mouse

Trypsin-1, also known as cationic trypsinogen, is a protein that in humans is encoded by the PRSS1 gene. Trypsin-1 is the main isoform of trypsinogen secreted by pancreas, the others are trypsin-2 (anionic trypsinogen), and trypsin-3 (meso-trypsinogen).