PRKRA

PRKRA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DIX
Identifiers
Aliases	PRKRA, DYT16, PACT, RAX, HSD14, protein activator of interferon induced protein kinase EIF2AK2
External IDs	OMIM: 603424; MGI: 1344375; HomoloGene: 2738; GeneCards: PRKRA; OMA:PRKRA - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	178,451,512 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	76,478,359 bp
RNA expression pattern
	Top expressed in
	sperm; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; right ventricle; ; gastrocnemius muscle; ; muscle of thigh; ; thoracic diaphragm; ; tibial arteries; ; Descending thoracic aorta; ; ganglionic eminence;
	Top expressed in
	interventricular septum; ; endocardial cushion; ; medullary collecting duct; ; fossa; ; renal corpuscle; ; medial ganglionic eminence; ; condyle; ; otic vesicle; ; atrioventricular valve; ; neural tube;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; protein binding; identical protein binding; enzyme binding; double-stranded RNA binding; enzyme activator activity; RNA binding; pre-miRNA binding;
Cellular component	cytoplasm; membrane; intracellular anatomical structure; nucleoplasm; perinuclear region of cytoplasm; cytosol; RISC-loading complex;
Biological process	skeletal system morphogenesis; response to virus; outer ear morphogenesis; pre-miRNA processing; protein phosphorylation; immune response; middle ear morphogenesis; cellular response to oxidative stress; positive regulation of intrinsic apoptotic signaling pathway; negative regulation of cell population proliferation; production of miRNAs involved in gene silencing by miRNA; positive regulation of catalytic activity; protein stabilization; miRNA metabolic process; production of siRNA involved in RNA interference; gene silencing; viral process; ear development;
	Sources:Amigo / QuickGO
Orthologs
	8575
	23992
	ENSG00000180228
	ENSMUSG00000002731
	O75569
	Q9WTX2
	NM_001139517; NM_001139518; NM_001316362; NM_003690
	NM_011871
	NP_001132989; NP_001132990; NP_001303291; NP_003681
	NP_036001
	Wikidata
View/Edit Human	View/Edit Mouse

Protein kinase, interferon-inducible double stranded RNA dependent activator, also known as interferon-inducible double stranded RNA-dependent protein kinase activator A or Protein ACTivator of the interferon-induced protein kinase (PACT) is a protein that in humans is encoded by the PRKRA gene. PACT heterodimerizes with and activates protein kinase R. PRKRA mutations have been linked to a rare form of dystonia parkinsonism.