PRKCSH

PRKCSH
Identifiers
Aliases	PRKCSH, AGE-R2, G19P1, PCLD, PKCSH, PLD1, GIIB, VASAP-60, protein kinase C substrate 80K-H, PCLD1
External IDs	OMIM: 177060; MGI: 107877; HomoloGene: 2056; GeneCards: PRKCSH; OMA:PRKCSH - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	11,450,968 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	21,925,518 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; beta cell; ; olfactory bulb; ; left ovary; ; right ovary; ; C1 segment; ; granulocyte; ; right uterine tube; ; body of pancreas; ; body of uterus;
	Top expressed in
	choroid plexus of fourth ventricle; ; saccule; ; yolk sac; ; gastrula; ; calvaria; ; otic vesicle; ; epiblast; ; right kidney; ; decidua; ; somite;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; phosphoprotein binding; transmembrane transporter binding; metal ion binding; protein kinase C binding; protein binding;
Cellular component	endoplasmic reticulum lumen; intracellular anatomical structure; endoplasmic reticulum; glucosidase II complex; intracellular membrane-bounded organelle;
Biological process	N-glycan processing; intracellular signal transduction; post-translational protein modification; protein folding;
	Sources:Amigo / QuickGO
Orthologs
	5589
	19089
	ENSG00000130175
	ENSMUSG00000003402
	P14314
	O08795
NM_001001329; NM_001289102; NM_001289103; NM_001289104; NM_002743;
	NM_001379608; NM_001379609
	NM_001293650; NM_001293651; NM_008925
NP_001001329; NP_001276031; NP_001276032; NP_001276033; NP_002734;
	NP_001366537; NP_001366538
	NP_001280579; NP_001280580; NP_032951
	Wikidata
View/Edit Human	View/Edit Mouse

Glucosidase 2 subunit beta is an enzyme that in humans is encoded by the PRKCSH gene.

This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum (ER). This protein is an acidic phospho-protein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease (PCLD). Alternatively spliced transcript variants encoding distinct isoforms have been observed.