PRKAB2

PRKAB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2F15, 2V8Q, 2V92, 2V9J, 2Y8L, 2Y8Q, 2YA3, 4CFH, 4EAI, 4EAJ, 4RER, 4REW
Identifiers
Aliases	PRKAB2, protein kinase AMP-activated non-catalytic subunit beta 2
External IDs	OMIM: 602741; MGI: 1336185; HomoloGene: 38046; GeneCards: PRKAB2; OMA:PRKAB2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	147,172,550 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	97,581,128 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; Skeletal muscle tissue of biceps brachii; ; gastrocnemius muscle; ; body of tongue; ; saphenous vein; ; muscle of thigh; ; buccal mucosa cell; ; tibial arteries;
	Top expressed in
	epithelium of lens; ; knee joint; ; medial head of gastrocnemius muscle; ; quadriceps femoris muscle; ; facial motor nucleus; ; muscle of thigh; ; triceps brachii muscle; ; ascending aorta; ; tibialis anterior muscle; ; vastus lateralis muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	AMP-activated protein kinase activity; protein binding; identical protein binding; protein kinase binding;
Cellular component	cytosol; nucleoplasm; nucleotide-activated protein kinase complex; nucleus; cytoplasm;
Biological process	lipid metabolism; regulation of fatty acid biosynthetic process; fatty acid metabolic process; fatty acid biosynthetic process; macroautophagy; protein phosphorylation; signal transduction; regulation of catalytic activity; positive regulation of cold-induced thermogenesis; carnitine shuttle; regulation of macroautophagy; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	5565
	108097
	ENSG00000131791
	ENSMUSG00000038205
	O43741
	Q6PAM0
	NM_005399
	NM_182997
	NP_005390
	NP_892042
	Wikidata
View/Edit Human	View/Edit Mouse

5'-AMP-activated protein kinase subunit beta-2 is an enzyme that in humans is encoded by the PRKAB2 gene.

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles.