PRDX5

PRDX5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H4O, 1HD2, 1OC3, 1URM, 2VL2, 2VL3, 2VL9, 3MNG, 4K7I, 4K7N, 4K7O, 4MMM
Identifiers
Aliases	PRDX5, ACR1, AOEB166, B166, HEL-S-55, PLP, PMP20, PRDX6, PRXV, prx-V, SBBI10, peroxiredoxin 5
External IDs	OMIM: 606583; MGI: 1859821; HomoloGene: 8076; GeneCards: PRDX5; OMA:PRDX5 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	64,321,811 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	6,887,474 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; epithelium of nasopharynx; ; palpebral conjunctiva; ; right uterine tube; ; mucosa of transverse colon; ; apex of heart; ; olfactory zone of nasal mucosa; ; right adrenal gland; ; right adrenal cortex; ; right lobe of thyroid gland;
	Top expressed in
	granulocyte; ; right kidney; ; human kidney; ; dentate gyrus of hippocampal formation granule cell; ; choroid plexus of fourth ventricle; ; medial vestibular nucleus; ; vestibular membrane of cochlear duct; ; lip; ; deep cerebellar nuclei; ; transitional epithelium of urinary bladder;
	More reference expression data
	n/a
Gene ontology
Molecular function	peroxynitrite reductase activity; protein dimerization activity; peroxidase activity; RNA polymerase III transcription regulatory region sequence-specific DNA binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; antioxidant activity; peroxiredoxin activity; oxidoreductase activity; signaling receptor binding; thioredoxin peroxidase activity; protein binding;
Cellular component	cytoplasm; cytosol; intracellular membrane-bounded organelle; peroxisome; mitochondrial matrix; mitochondrion; perinuclear region of cytoplasm; extracellular exosome; cytoplasmic vesicle; nucleus; extracellular space; peroxisomal matrix;
Biological process	positive regulation of collagen biosynthetic process; NADPH oxidation; negative regulation of apoptotic process; response to oxidative stress; cellular response to reactive oxygen species; regulation of apoptosis involved in tissue homeostasis; negative regulation of transcription by RNA polymerase III; negative regulation of oxidoreductase activity; hydrogen peroxide catabolic process; reactive nitrogen species metabolic process; inflammatory response; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cellular oxidant detoxification; cell redox homeostasis; apoptotic process; cellular response to oxidative stress;
	Sources:Amigo / QuickGO
Orthologs
	25824
	54683
	ENSG00000126432
	ENSMUSG00000024953
	P30044
	P99029
	NM_012094; NM_181651; NM_181652; NM_001358511; NM_001358516
	NM_012021; NM_001358444
	NP_036226; NP_857634; NP_857635; NP_001345440; NP_001345445
	NP_036151; NP_001345373
	Wikidata
View/Edit Human	View/Edit Mouse

Peroxiredoxin-5 (PRDX5), mitochondrial is a protein that in humans is encoded by the PRDX5 gene, located on chromosome 11.

This gene encodes a member of the six-member peroxiredoxin family of antioxidant enzymes. Like the other five members, PRDX5 is widely expressed in tissues but differs by its large subcellular distribution. In human cells, it has been shown that PRDX5 can be localized to mitochondria, peroxisomes, the cytosol, and the nucleus. Human PRDX5 is identified by virtue of the sequence homologies to yeast peroxisomal antioxidant enzyme PMP20.

Biochemically, PRDX5 is a peroxidase that can use cytosolic or mitochondrial thioredoxins to reduce alkyl hydroperoxides or peroxynitrite with high rate constants in the 10⁶ to 10⁷ M⁻¹s⁻¹ range, whereas its reaction with hydrogen peroxide is more modest, in the 10⁵ M⁻¹s⁻¹ range. So far, PRDX5 has been shown to be a cytoprotective antioxidant enzyme that inhibits endogenous or exogenous peroxide accumulation.