PPIL2

PPIL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZKC
Identifiers
Aliases	PPIL2, CYC4, CYP60, Cyp-60, UBOX7, hCyP-60, peptidylprolyl isomerase like 2
External IDs	OMIM: 607588; MGI: 2447857; HomoloGene: 8643; GeneCards: PPIL2; OMA:PPIL2 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	21,700,015 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	16,929,121 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; granulocyte; ; body of pancreas; ; gastric mucosa; ; minor salivary glands; ; apex of heart; ; body of stomach; ; nipple; ; anterior pituitary;
	Top expressed in
	spermatocyte; ; spermatid; ; genital tubercle; ; tail of embryo; ; ventricular zone; ; thymus; ; neural layer of retina; ; neural tube; ; right kidney; ; granulocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	ubiquitin-ubiquitin ligase activity; protein binding; isomerase activity; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; transferase activity; peptidyl-prolyl cis-trans isomerase activity; cyclosporin A binding;
Cellular component	cytoplasm; Golgi lumen; plasma membrane; nucleus; nucleoplasm;
Biological process	protein polyubiquitination; protein localization to plasma membrane; protein folding; protein ubiquitination; leukocyte migration; protein peptidyl-prolyl isomerization;
	Sources:Amigo / QuickGO
Orthologs
	23759
	66053
	ENSG00000100023
	ENSMUSG00000022771
	Q13356
	Q9D787
	NM_014337; NM_148175; NM_148176; NM_001317996
	NM_001252444; NM_001252445; NM_144954; NM_001356386
	NP_001304925; NP_055152; NP_680480; NP_680481
	NP_001239373; NP_001239374; NP_659203; NP_001343315
	Wikidata
View/Edit Human	View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase-like 2 is an enzyme that in humans is encoded by the PPIL2 gene.

This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Multiple transcript variants encoding different isoforms have been found for this gene.