PPIL1

PPIL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XWN, 2K7N, 2X7K
Identifiers
Aliases	PPIL1, CYPL1, PPIase, hCyPX, CGI-124, peptidylprolyl isomerase like 1, PCH14
External IDs	OMIM: 601301; MGI: 1916066; HomoloGene: 9367; GeneCards: PPIL1; OMA:PPIL1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	36,874,803 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	29,483,160 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; myocardium of left ventricle; ; oocyte; ; gonad; ; cardiac muscle tissue of right atrium; ; secondary oocyte; ; right auricle of heart; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex;
	Top expressed in
	embryo; ; ventricular zone; ; superior cervical ganglion; ; morula; ; embryo; ; neural tube; ; blastocyst; ; epiblast; ; yolk sac; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	isomerase activity; protein binding; disordered domain specific binding; peptidyl-prolyl cis-trans isomerase activity; cyclosporin A binding;
Cellular component	catalytic step 2 spliceosome; spliceosomal complex; nucleoplasm; nucleus; U2-type catalytic step 2 spliceosome;
Biological process	mRNA processing; protein folding; RNA splicing; mRNA splicing, via spliceosome; protein peptidyl-prolyl isomerization;
	Sources:Amigo / QuickGO
Orthologs
	51645
	68816
	ENSG00000137168
	ENSMUSG00000024007
	Q9Y3C6
	Q9D0W5
	NM_016059
	NM_026845
	NP_057143
	NP_081121
	Wikidata
View/Edit Human	View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase-like 1 is an enzyme that in humans is encoded by the PPIL1 gene.

This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions.

Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.