PPIE (gene)

PPIE
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZMF, 2CQB, 2KU7, 2KYX, 2R99, 3LPY, 3MDF, 3UCH
Identifiers
Aliases	PPIE, CYP-33, CYP33, peptidylprolyl isomerase E
External IDs	OMIM: 602435; MGI: 1917118; HomoloGene: 38142; GeneCards: PPIE; OMA:PPIE - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	39,763,914 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	123,033,744 bp
RNA expression pattern
	Top expressed in
	left testis; ; right uterine tube; ; right testis; ; body of pancreas; ; granulocyte; ; Descending thoracic aorta; ; islet of Langerhans; ; muscle layer of sigmoid colon; ; popliteal artery; ; tibial arteries;
	Top expressed in
	blastocyst; ; ventricular zone; ; morula; ; embryo; ; yolk sac; ; embryo; ; neural layer of retina; ; epiblast; ; otic placode; ; primitive streak;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	isomerase activity; peptidyl-prolyl cis-trans isomerase activity; protein binding; nucleic acid binding; cyclosporin A binding; RNA binding; mRNA binding; poly(A) binding; unfolded protein binding;
Cellular component	catalytic step 2 spliceosome; nucleoplasm; spliceosomal complex; nucleus; extracellular region; cytosol; nuclear speck; secretory granule lumen; ficolin-1-rich granule lumen; U2-type catalytic step 2 spliceosome;
Biological process	regulation of transcription, DNA-templated; mRNA processing; protein peptidyl-prolyl isomerization; protein folding; RNA splicing; positive regulation of viral genome replication; transcription-coupled nucleotide-excision repair; mRNA splicing, via spliceosome; neutrophil degranulation; protein refolding;
	Sources:Amigo / QuickGO
Orthologs
	10450
	56031
	ENSG00000084072
	ENSMUSG00000028651
	Q9UNP9
	Q9QZH3
	NM_001195007; NM_006112; NM_203456; NM_203457; NM_001319293
	NM_019489
	NP_001181936; NP_001306222; NP_006103; NP_982281
	NP_062362
	Wikidata
View/Edit Human	View/Edit Mouse

Peptidylprolyl isomerase E (cyclophilin E), also known as PPIE, is an enzyme which in humans is encoded by the PPIE gene on chromosome 1. As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to facilitate folding or repair of proteins. In addition, PPIE participates in many biological processes, including mitochondrial metabolism, apoptosis, and inflammation, as well as related diseases and conditions, such as ischemic reperfusion injury, AIDS, influenza, and cancer.