PPIB

PPIB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CYN, 3ICH, 3ICI
Identifiers
Aliases	PPIB, CYP-S1, CYPB, HEL-S-39, OI9, SCYLP, peptidylprolyl isomerase B, B
External IDs	OMIM: 123841; MGI: 97750; HomoloGene: 726; GeneCards: PPIB; OMA:PPIB - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	64,163,134 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	65,973,905 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; corpus epididymis; ; caput epididymis; ; right lobe of thyroid gland; ; anterior pituitary; ; seminal vesicula; ; left lobe of thyroid gland; ; parotid gland; ; tail of epididymis; ; pericardium;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; vestibular sensory epithelium; ; fossa; ; vas deferens; ; condyle; ; endothelial cell of lymphatic vessel; ; Paneth cell; ; utricle; ; efferent ductule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	collagen binding; unfolded protein binding; protein-containing complex binding; isomerase activity; protein binding; RNA polymerase binding; RNA binding; peptidyl-prolyl cis-trans isomerase activity; cyclosporin A binding;
Cellular component	protein-containing complex; endoplasmic reticulum lumen; membrane; focal adhesion; melanosome; smooth endoplasmic reticulum; endoplasmic reticulum chaperone complex; endoplasmic reticulum; perinuclear region of cytoplasm; extracellular exosome; nucleus;
Biological process	protein stabilization; regulation of post-translational protein modification; protein peptidyl-prolyl isomerization; positive regulation by host of viral genome replication; positive regulation by host of viral process; protein folding; positive regulation of multicellular organism growth; bone development; chaperone-mediated protein folding; protein refolding;
	Sources:Amigo / QuickGO
Orthologs
	5479
	19035
	ENSG00000166794
	ENSMUSG00000032383
	P23284
	P24369
	NM_000942
	NM_011149
	NP_000933
	NP_035279
	Wikidata
View/Edit Human	View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase B is an enzyme that is encoded by the PPIB gene. As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to regulate protein folding of type I collagen. Generally, PPIases are found in all eubacteria and eukaryotes, as well as in a few archaebacteria, and thus are highly conserved.