POLR3K

POLR3K
Identifiers
Aliases	POLR3K, C11, C11-RNP3, RPC10, RPC11, RPC12.5, My010, polymerase (RNA) III subunit K, RNA polymerase III subunit K, HLD21
External IDs	OMIM: 606007; MGI: 1914255; HomoloGene: 5610; GeneCards: POLR3K; OMA:POLR3K - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	53,608 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	181,512,623 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; prefrontal cortex; ; gonad; ; biceps brachii; ; thoracic diaphragm; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; monocyte; ; anterior cingulate cortex; ; granulocyte;
	Top expressed in
	ciliary body; ; retinal pigment epithelium; ; iris; ; medial ganglionic eminence; ; otic placode; ; abdominal wall; ; maxillary prominence; ; mandibular prominence; ; primitive streak; ; urothelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding; DNA-directed 5'-3' RNA polymerase activity; zinc ion binding; metal ion binding; RNA polymerase III activity;
Cellular component	RNA polymerase III complex; cytosol; nucleolus; nucleus; nucleoplasm;
Biological process	immune system process; defense response to virus; transcription, DNA-templated; transcription by RNA polymerase III; innate immune response; termination of RNA polymerase III transcription; tRNA 3'-trailer cleavage; positive regulation of type I interferon production;
	Sources:Amigo / QuickGO
Orthologs
	51728
	67005
	ENSG00000161980
	ENSMUSG00000038628
	Q9Y2Y1
	Q9CQZ7
	NM_016310
	NM_025901
	NP_057394
	NP_080177
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-directed RNA polymerase III subunit RPC10 is an enzyme that in humans is encoded by the POLR3K gene.

This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes.

The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription.