PNPLA8

PNPLA8
Identifiers
Aliases	PNPLA8, IPLA2(GAMMA), IPLA2-2, IPLA2G, iPLA2gamma, MMLA, PNPLA-gamma, patatin like phospholipase domain containing 8
External IDs	OMIM: 612123; MGI: 1914702; HomoloGene: 12136; GeneCards: PNPLA8; OMA:PNPLA8 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	108,569,666 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	44,369,315 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; pancreatic epithelial cell; ; tibialis anterior muscle; ; deltoid muscle; ; entorhinal cortex; ; myocardium of left ventricle; ; pars compacta; ; right ventricle; ; pars reticulata; ; corpus callosum;
	Top expressed in
	muscle of thigh; ; brown adipose tissue; ; intercostal muscle; ; vastus lateralis muscle; ; temporal muscle; ; myocardium of ventricle; ; sternocleidomastoid muscle; ; triceps brachii muscle; ; mammary gland; ; soleus muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	lysophospholipase activity; calcium-independent phospholipase A2 activity; hydrolase activity; ATP binding; phospholipase A2 activity;
Cellular component	cytoplasm; integral component of membrane; Golgi apparatus; endoplasmic reticulum membrane; membrane; Golgi membrane; peroxisomal membrane; peroxisome; intracellular anatomical structure; endoplasmic reticulum; perinuclear region of cytoplasm;
Biological process	linoleic acid metabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine catabolic process; lipid metabolism; cell death; fatty acid metabolic process; lipid catabolic process; phosphatidylethanolamine catabolic process; prostaglandin biosynthetic process; metabolism; arachidonic acid metabolic process; phosphatidylcholine acyl-chain remodeling; arachidonic acid secretion;
	Sources:Amigo / QuickGO
Orthologs
	50640
	67452
	ENSG00000135241
	ENSMUSG00000036257
	Q9NP80
	Q8K1N1
NM_001256007; NM_001256008; NM_001256009; NM_001256010; NM_001256011;
	NM_015723
	NM_026164
NP_001242936; NP_001242937; NP_001242938; NP_001242939; NP_001242940;
	NP_056538
	NP_080440
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium-independent phospholipase A2-gamma is an enzyme that in humans is encoded by the PNPLA8 gene.